Acetylsalicylic Acid
Acetylsalicylic Acid (Aspirin) Storyboard
Drug Name & Classification
Sailor who cycles
Acetylsalicylic acid (A-sailor-cycling-acid)
National Social AID (NSAID) organization
Drug Class: NSAID (Non-Steroidal Anti-Inflammatory Drug)
Stopping delivery of unsafe dinner plates
Antiplatelet agent (prevents platelet aggregation)
Acetyl stamp
Irreversible inhibition via acetylation of the COX enzyme
Indications
Traffic jams trapped by dirty, sticky delivery plates
Thrombosis, Myocardial Infarction (MI), and Stroke caused by platelet aggregation blocking blood vessels
Patrolling to stamp plates before jams start
Prophylactic use (primary and secondary prevention) for MI and Stroke
Mechanism of Action & Dosing
Cyclo-oxygenase 1 unicycle (1 wheel)
COX-1 Inhibition
Going slow / Low speed (~100 mg/day)
Low-dose Aspirin (~75–100 mg/day): Selectively targets COX-1 for antiplatelet effect
Permanently banned plates; replacement takes 7–10 days
Irreversible inhibition of platelets; life span of platelets is 7 to 10 days
Cyclo-oxygenase 2 bicycle (2 wheels)
COX-2 Inhibition
Medium speed (200–2000 mg/day) for angry businessmen (red/fever, pain)
Medium-dose Aspirin: Analgesic (pain relief) and Antipyretic (fever reduction) effects
Maximum speed (2000–4000 mg/day) for city-wide inflammatory riots
High-dose Aspirin: Anti-inflammatory effect
Adverse Effects & Interactions
Special teeth on tyres scraping the protective mucosal lining
COX-1 inhibition reduces protective gastric mucosal synthesis (PGE2/PGI2), leading to gastric ulcers
Too many officers clearing plates making roads slippery
Concomitant use with other NSAIDs/anticoagulants increases bleeding risk
High-speed pedalling causing high-pitched ringing sound
Tinnitus (a classic sign of Aspirin toxicity / Salicylism)
Debris splashing onto water pipes, rusting and clogging them
Tubulointerstitial nephritis and decreased renal perfusion (kidney injury caused by chronic NSAID use)
Member discussion